Virology / Proteomics / Neurotropism
Stanford, CaliforniaPostdoctoral Fellow · Stanford University
Systems virology &
viral neurotropism
BIOGRAPHY
I am a CZ Biohub Collaborative Postdoctoral Fellow working jointly with the Huttenhain lab at Stanford University and the Arias Group at the Chan Zuckerberg Biohub San Francisco.
My research focuses on the molecular mechanisms of viral neurotropism and their consequences for host cells. I combine molecular virology, proteomics, CRISPR genetic screens, single-cell transcriptomics, and computational analysis to study how viruses enter and alter neurons.
I conducted my doctoral research at the Spanish National Research Council (CSIC), where I used multi-omic approaches to study poxvirus–host interactions.
RESEARCH QUESTIONS
Molecular mechanisms of viral entry into neurons and other central nervous system cells, and the cellular damage associated with infection.
Proteomic profiling and multi-omics integration to map changes in cellular states and host pathways.
Computational approaches to identify vulnerable host pathways and generate experimentally testable hypotheses.
A preprint using human iPSC-derived neurons to define the molecular signatures of West Nile virus neuropathogenesis, revealing strain-dependent differences in neuronal infection and neuroattenuation.
A review of proteomic approaches for resolving cellular signaling across space and time, spanning organelle-resolved proteomics, subcellular protein mapping, and emerging spatial phosphoproteomic strategies.
A preprint describing V-SWITCH, a modular single-vector fluorescent reporter designed to detect live RNA virus infections in living cells.
A systems-level study of Vaccinia virus infection dynamics that combines single-cell transcriptomics with proteomics to resolve how host responses evolve across infection.
A software-oriented contribution focused on aggregating and visualizing multiple MaGeCK screen datasets in a more streamlined and interpretable way.
Preclinical vaccine study showing robust protection with an MVA platform expressing a prefusion-stabilized SARS-CoV-2 spike, including prevention of detectable brain infection in mice.
Genome-wide screening work identifying host factors involved in Vaccinia virus infection, including β2-microglobulin as a previously unrecognized entry-related factor.
A review of classical and emerging strategies for engineering poxvirus genomes, with relevance to recombinant vaccines, biotechnology, and reverse genetics.
11/2024 – 11/2026
CZ Biohub and Stanford University, CA, USA
11/2023 – 10/2024
Stanford University, CA, USA
07/2023 – 09/2023
INIA-CSIC, Madrid, Spain
09/2019 – 07/2023
INIA-CSIC, Madrid, Spain
07/2022 – 11/2022
Chan Zuckerberg Biohub, San Francisco, CA, USA
01/2018 – 06/2018
Dept. Organic Chemistry, Universidad Autónoma de Madrid, Spain
06/2015 – 06/2016
National Center for Biotechnology – CSIC, Madrid, Spain
09/2019 – 09/2023
Universidad Autónoma de Madrid, Madrid, Spain
06/2021 – 06/2022
Universidad Pablo de Olavide, Sevilla, Spain
09/2017 – 06/2018
Universidad Autónoma de Madrid, Madrid, Spain
09/2012 – 06/2017
Universidad Autónoma de Madrid, Madrid, Spain